| Date & Time | Favorite | Spread | Underdog |
| 10/5 1:00 ET | At Carolina | -1 | Chicago |
| 10/5 1:00 ET | Cleveland | -1 | At Tennessee |
| 10/5 1:00 ET | At Philadelphia | -4.5 | St. Louis |
| 10/5 1:00 ET | At NY Giants | -4 | Atlanta |
| 10/5 1:00 ET | At New Orleans | -10 | Tampa Bay |
| 10/5 1:00 ET | At Dallas | -5.5 | Houston |
| 10/5 1:00 ET | At Detroit | -5.5 | Buffalo |
| 10/5 1:00 ET | At Indianapolis | -3 | Baltimore |
| 10/5 1:00 ET | Pittsburgh | -6 | At Jacksonville |
| 10/5 4:05 ET | At Denver | -7.5 | Arizona |
| 10/5 4:25 ET | At San Francisco | -4.5. | Kansas City |
| 10/5 4:25 ET | At San Diego | -6.5 | NY Jets |
| 10/5 8:30 ET | Cincinnati | -2.5 | At New England |
| 10/6 8:30 ET | Seattle | -7 | At Washington |
- Carolina comes into this game losing two games in a row. Chicago just got creamed by the Packers in the 2nd half against the Packers. While the Panthers are dangerously low on running backs, I still think Carolina will find a way to win this one.
- The Tennessee Titans are getting Jake Locker back but Cleveland is coming off a bye and appear to be a decent team. It may be tough to get it done on the road but I'm taking Cleveland
- The St. Louis Rams are struggling. While Foles and the Eagles offense did struggle against the 49ers, I expect Chip Kelley and company to rebound from an abysmal performance where their special teams had 3 touchdowns and their offense had none. Also, it's hard to get behind whichever quarterback St. Louis throws out there. I have the Eagles.
- The Falcons won a close game against the Vikings last week even though Terry Bridgewater got going. Still, the Giants are playing with a lot of momentum, their defense is playing well, and I don't like the Falcons defense that much. I'm going with the Giants.
- New Orleans is a different team at home. While the Buccaneers are coming off a win at Pittsburgh, it is hard to believe that they will have similar success here against New Orleans.
- Dallas is running the ball well and their defense is playing well. Perhaps if Houston had a better QB I could go with the Texans, but I think Dallas wins comfortably while extending their winning streak.
- Kyle Orton makes his first start for the Bills. Still Detroit is playing well. I'm not seeing a letdown for them here especially since Calvin Johnson is due for a big game. Detroit takes it.
- Baltimore is playing well and Indianapolis has beaten up on some lesser teams in their division. I think Indianapolis will struggle to contain Baltimore's offense while the Ravens defense should do enough to contain Andrew Luck. Baltimore should take this one.
- Pittsburgh is coming off a disappointing loss to the Bucs. You have to think that the Steelers will get their act together against the Jaguars.
- Denver should win this game, but I have the Cardinals covering
- I have the Chargers covering here.
- New England offense didn't look good against the Chiefs and the Bengals defense is probably better plus Cincinnati is coming off a bye. Bengals should win here.
- I have a feeling Washington will play the Seahawks close but ultimately lose. I have Kirk Cousins having a better showing and the Redskins covering here.
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